Policies Composition Based on Data Usage Context

International audienceIn federated query processing, different datasets can be queried simultaneously. Each dataset has different privacy policies attached, but,which privacy policy will govern the usage of the query result? In this work we propose a mechanism, based on semantic web technologies, tocompose privacy policies. The originality of our approach is that our composition rules are based on the data usage context and deduced implicitterms

Profile, evolution and characteristics of Golf course management organizations in Spain

Debido a la creciente subida de ingresos en el sector del golf de los últimos tiempos, el objetivo del presente trabajo fue conocer el perfil y características de las organizaciones deportivas que están detrás del citado aumento. Para ello se analizó datos estructurales como el tamaño, antigüedad, personalidad jurídica, número de empleados, y evolución económica como el total de activos e ingresos de explotación de estas organizaciones de este sector del golf en España.Due to the increasing income increase in the golf sector of recent times, the objective of this work was to know the profile and characteristics of the sports organizations that are behind the aforementioned increase. For this, structural data was analyzed, such as the size, seniority, legal personality and number of employees, and economic evolution as the total assets and operating income of these organizations in this sector of golf in Spain

Assessment of reliability and validity of the Spanish version of the Nursing Students’ Perception of Instructor Caring (S-NSPIC)

The care that clinical instructors demonstrate to students is essential for their education, considering the strong impact it has on their future relationships with patients, relatives, and other health professionals. Nursing Students’ Perceptions of Instructor Caring (NSPIC) is an instrument designed to assess nursing students’ perceptions of instructor’s caring behaviors. A trans-cultural, conceptual, and psychometric validation study was conducted with 315 nursing students at the University of Seville during their clinical practices in three regional hospitals. The NSPIC was translated and adapted to Spanish. The content validity was established by a panel of experts. To assess concurrent validity the culturally adapted Spanish version of the Clinical Placement Evaluation Tool (CPET) was used as a gold standard. The construct validity was determined by an exploratory factor analysis to identify the internal structure of the NSPIC-S. The internal consistency was established by Cronbach’s α and the intra-observer reliability for each item was established by test-retest. The content validity index varied between 0.53 and 0.93 and the correlation to the CPET was moderate. The factor analysis revealed a structure of five factors, one of which differed from the original scale. The value of Cronbach’s α was 0.95 and intraclass correlation coefficients varied between 0.5 and 0.89. Our study provided a culturally adapted version of the NSPIC, valid and reliable to be used in the Spanish context, the NSPIC-S

Evaluación de la granulometría del GTR (Ground Tire Rubber) mediante los modelos de Rosin-Ramler y de Gates-Gaudin-Schuhmann

En este trabajo se presenta un estudio granulométrico del polvo de granulometría 0,2 mm. Se han empleado 8 tamices diferentes, y se ha realizado con dos valores de potencia en el equipo CISA RP.09: a 6 y a 10, manteniendo el tiempo en 15 minutos. Se han analizado los valores medios obtenidos en gramos retenidos en cada tamiz. Se concluye que la mayor parte de la masa tamizada se acumula en 4 tamices, aunque al eliminar los tamices que retienen menos de un 3%, la retención principal se acumula en sólo tres tamices. A continuación se realiza el estudio de distribución granulométrica del porcentaje retenido y acumulado. Se estudió la función de distribución granulométrica y se comprobó que se ajustaba al modelo de Rosin-Ramler con un valor de pendiente de 2,58 y con un valor de ordenada en el origen de 0,48.Nadal Gisbert, AV.; Boix García, M.; Crespo Amorós, JE.; Macías García, A. (2015). Evaluación de la granulometría del GTR (Ground Tire Rubber) mediante los modelos de Rosin-Ramler y de Gates-Gaudin-Schuhmann. Compobell. http://hdl.handle.net/10251/71806

SAR studies of epoxycurcuphenol derivatives on leukemia CT-CD4 cells

Bioactive natural products are a potential source of new pharmaceuticals since they offer new modes of action and more specific activities. The use of derivatization also enables the optimal structure for their biological activity to be determined. In this study several epoxycurcuphenol derivatives were synthesized. The substitution pattern on the aromatic and oxirane rings was varied along with that at the benzylic position and the length of the side chain was altered. These changes were made in order to gain a deeper understanding of the structural requirements for activity. The biological activities of these compounds were evaluated on the human leukemia cell line Jurkat using an antiproliferative assay. The activity results and structural requirements are discussed

La Paleopalinología en el Laboratorio de Arqueobotánica del Departamento de Prehistoria, Instituto de Historia, CSIC: 1977-2002

Taking the opportunity to commemorate the 25th anniversary of the Laboratory of Archaeobotany of the Department of Prehistory (Institute of History, CSIC), this paper presents its activity through this period: projects, research themes and the literature published by its researchers.Con motivo de los 25 años de la puesta en marcha del Laboratorio de Arqueobotánica del Departamento de Prehistoria (Instituto de Historia, CSIC) se presentan los resultados de su actividad a lo largo de este periodo de tiempo: proyectos, líneas de investigación abordadas y bibliografía generada en su seno

Social Positioning Analysis as a Qualitative Methodology to Study Identity Construction in People Diagnosed With Severe Mental Illnesses

Severe mental illnesses (SMI) in general, and schizophrenia in particular, have been characterized as alterations of the experience of self and identity. When first diagnosed with SMI, the subjective experiences and specific narrative challenges faced by this population are particularly important. Therefore, qualitative approaches which allow to analyze these subjective experiences should be developed. This article presents in detail a specific method, called Social Positioning Analysis, which makes the complexity of narratives and life stories with multiple turning points understandable. To develop this methodological proposal, it has been taken into account the performative aspects of social interaction in which narratives are constructed. The methodology has previously been used in other health contexts and is innovative in the field of mental health. Linguistic criteria, definitions, and multiple examples are included to facilitate its application, as well as some reflections about its potential and possible benefits.Los trastornos mentales graves (TMG) en general, y la esquizofrenia en particular, se han caracterizado como alteraciones de la experiencia del yo y de la identidad. Cuando se diagnostica por primera vez con TMG, las experiencias subjetivas y los desafíos narrativos específicos que enfrenta esta población son particularmente importantes. Por tanto, conviene desarrollar enfoques cualitativos que permitan analizar estas experiencias subjetivas. Este artículo presenta en detalle un método específico, denominado Social Positioning Analysis, que permite comprender la complejidad de las narrativas e historias de vida con múltiples puntos de inflexión. Para desarrollar esta propuesta metodológica se ha tenido en cuenta los aspectos performativos de la interacción social en los que se construyen dichas narrativas. La metodología ha sido utilizada previamente en otros contextos de salud y es innovadora en el campo de la salud mental. Se incluyen criterios lingüísticos, definiciones y múltiples ejemplos para facilitar su aplicación, así como algunas reflexiones sobre sus potenciales y posibles beneficios.Gobierno de España, Ministerio de Ciencia e Innovación PSI2016–80112–

Diclofenac N-Derivatives as Therapeutic Agents with Anti-Inflammatory and Anti-Cancer Effect

A series of diclofenac N-derivatives (2, 4, 6, 8c, 9c, 10a-c) were synthesized in order to test their anti-cancer and anti-inflammatory effects. The anticarcinogen activity has been assayed against three cancer cell lines: HT29, human colon cancer cells; Hep-G2, human hepatic cells; and B16-F10, murine melanoma cells. First, we determined the cytotoxicity of the different compounds, finding that the most effective compound was compound 8c against all cell lines and both compounds 4 and 6 in human Hep-G2 and HT29 cell lines. Compounds 4 and 8c were selected for the percentage of apoptosis determination, cell cycle distribution, and mitochondrial membrane potential measure because these products presented the lowest IC50 values in two of the three cancer cell lines assayed (B16-F10 and HepG2), and were two of the three products with lowest IC50 in HT29 cell line. Moreover, the percentages of apoptosis induction were determined for compounds 4 and 8c, showing that the highest values were between 30 to 60%. Next, the effects of these two compounds were observed on the cellular cycle, resulting in an increase in the cell population in G2/M cell cycle phase after treatment with product 8c, whereas compound 4 increased the cells in phase G0/G1, by possible differentiation process induction. Finally, to determine the possible apoptosis mechanism triggered by these compounds, mitochondrial potential was evaluated, indicating the possible activation of extrinsic apoptotic mechanism. On the other hand, we studied the anti-inflammatory effects of these diclofenac (DCF) derivatives on lipopolysaccharide (LPS) activated RAW 264.7 macrophagesmonocytes murine cells by inhibition of nitric oxide (NO) production. As a first step, we determined the cytotoxicity of the synthesized compounds, as well as DCF, against these cells. Then, sub-cytotoxic concentrations were used to determine NO release at different incubation times. The greatest antiinflammatory effect was observed for products 2, 4, 8c, 10a, 10b, and 9c at 20 µg·mL−1 concentration after 48 h of treatment, with inhibition of produced NO between 60 to 75%, and a concentration that reduces to the 50% the production of NO (IC50 NO) between 2.5 to 25 times lower than that of DCF. In this work, we synthesized and determined for the first time the anti-cancer and anti-inflammatory potential of eight diclofenac N-derivatives. In agreement with the recent evidences suggesting that inflammation may contribute to all states of tumorigenesis, the development of these new derivatives capable of inducing apoptosis and anti-inflammatory effects at very low concentrations represent new effective therapeutic strategies against these diseases.MINISTERIO DE ECONOMÍA Y COMPETITIVIDAD, PID2019-106222RB-C32/SRA (State Research Agency, 10.13039/501100011033)“Consejería de Economía, Conocimiento, Empresas y Universidad. Junta de Andalucía”, grant number B1-BIO-281-UGR1

Synthesis, antibacterial and antifungal activities of naphthoquinone derivatives: a structure–activity relationship study

The synthesis of 1,4-naphthoquinone derivatives is of great interest since these compounds exhibit strong activity as antimalarial, antibacterial, antifungal and anticancer agents. A series of 50 naphthoquinone derivatives was synthesized and evaluated for antibacterial and antifungal activity against Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis, Staphylococcus aureus, Candida krusei, Candida parapsilosis and Cryptococcus neoformans using the broth microdilution method. The Candida species were the most susceptible microorganisms. Halogen derivatives of 1,4-naphthoquinone presented strong activity, e.g., 2-bromo-5-hydroxy-1,4-naphthoquinone, which exhibited inhibition at an MIC of 16 lg/ mL in S. aureus, and 2-chloro-5,8-dihydroxy-1,4-naphthoquinone, with an MIC of 2 lg/mL in C. krusei. These compounds showed higher activity against fungi, but the antibacterial activities were very low. The study of structure–activity relationships is very important in the search for new antimicrobial drugs due to the limited therapeutic arsenal